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Different Effects of Cisplatin and Transplatin on the Higher-Order Structure of DNA and Gene Expression
Despite the effectiveness of cisplatin as an anticancer agent, its trans-isomer, transplatin, is clinically ineffective. Although both isomers target nuclear DNA, there is a large difference in the magnitude of their biological effects. Here, we compared their effects on gene expression in an in vit...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981875/ https://www.ncbi.nlm.nih.gov/pubmed/31861648 http://dx.doi.org/10.3390/ijms21010034 |