Discovery of an Orally Effective Factor IX-Transferrin Fusion Protein for Hemophilia B

Hemophilia B is a severe blood clotting disorder caused by the deficiency of factor IX (FIX). FIX is not bioavailable when given orally due to poor stability and permeability in the gastrointestinal tract. The feasibility of fusing FIX with transferrin (Tf) to enhance the oral bioavailability of FIX...

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Detalles Bibliográficos
Autores principales: Xie, Chen, Wang, Zhijun, Su, Yang, Wang, Jeffrey, Shen, Wei-Chiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981973/
https://www.ncbi.nlm.nih.gov/pubmed/31861459
http://dx.doi.org/10.3390/ijms21010021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981973/
https://www.ncbi.nlm.nih.gov/pubmed/31861459
http://dx.doi.org/10.3390/ijms21010021

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