Exploiting RAS Nucleotide Cycling as a Strategy for Drugging RAS-Driven Cancers

Oncogenic mutations in RAS genes result in the elevation of cellular active RAS protein levels and increased signal propagation through downstream pathways that drive tumor cell proliferation and survival. These gain-of-function mutations drive over 30% of all human cancers, presenting promising the...

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Detalles Bibliográficos
Autores principales: Mattox, Tyler E., Chen, Xi, Maxuitenko, Yulia Y., Keeton, Adam B., Piazza, Gary A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982188/
https://www.ncbi.nlm.nih.gov/pubmed/31878223
http://dx.doi.org/10.3390/ijms21010141

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982188/
https://www.ncbi.nlm.nih.gov/pubmed/31878223
http://dx.doi.org/10.3390/ijms21010141

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