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Exploiting RAS Nucleotide Cycling as a Strategy for Drugging RAS-Driven Cancers
Oncogenic mutations in RAS genes result in the elevation of cellular active RAS protein levels and increased signal propagation through downstream pathways that drive tumor cell proliferation and survival. These gain-of-function mutations drive over 30% of all human cancers, presenting promising the...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982188/ https://www.ncbi.nlm.nih.gov/pubmed/31878223 http://dx.doi.org/10.3390/ijms21010141 |