Disabling the Protease DDI2 Attenuates the Transcriptional Activity of NRF1 and Potentiates Proteasome Inhibitor Cytotoxicity

Proteasome inhibition is used therapeutically to induce proteotoxic stress and trigger apoptosis in cancer cells that are highly dependent on the proteasome. As a mechanism of resistance, inhibition of the cellular proteasome induces the synthesis of new, uninhibited proteasomes to restore proteasom...

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Detalles Bibliográficos
Autores principales: Northrop, Amy, Vangala, Janakiram R., Feygin, Alex, Radhakrishnan, Senthil K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982299/
https://www.ncbi.nlm.nih.gov/pubmed/31947743
http://dx.doi.org/10.3390/ijms21010327

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982299/
https://www.ncbi.nlm.nih.gov/pubmed/31947743
http://dx.doi.org/10.3390/ijms21010327

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