The Lifespan Extension Ability of Nicotinic Acid Depends on Whether the Intracellular NAD(+) Level Is Lower than the Sirtuin-Saturating Concentrations

Calorie restriction can extend lifespan by increasing intracellular nicotinamide adenine dinucleotide (NAD(+)), thereby upregulating the activity of sirtuins (Caenorhabditis elegans Sir-2.1; human SIRT1). Nicotinic acid (NA) can be metabolized to NAD(+); however, the calorie restriction mimetic (CRM...

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Detalles Bibliográficos
Autores principales: Yang, Nae-Cherng, Cho, Yu-Hung, Lee, Inn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982340/
https://www.ncbi.nlm.nih.gov/pubmed/31878234
http://dx.doi.org/10.3390/ijms21010142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982340/
https://www.ncbi.nlm.nih.gov/pubmed/31878234
http://dx.doi.org/10.3390/ijms21010142

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