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The Lifespan Extension Ability of Nicotinic Acid Depends on Whether the Intracellular NAD(+) Level Is Lower than the Sirtuin-Saturating Concentrations
Calorie restriction can extend lifespan by increasing intracellular nicotinamide adenine dinucleotide (NAD(+)), thereby upregulating the activity of sirtuins (Caenorhabditis elegans Sir-2.1; human SIRT1). Nicotinic acid (NA) can be metabolized to NAD(+); however, the calorie restriction mimetic (CRM...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982340/ https://www.ncbi.nlm.nih.gov/pubmed/31878234 http://dx.doi.org/10.3390/ijms21010142 |