Regulation of PTP1B activation through disruption of redox-complex formation

We have identified a molecular interaction between the reversibly oxidized form of PTP1B and 14-3-3ζ that regulates PTP1B activity. Destabilizing the transient interaction between 14-3-3ζ and PTP1B, prevented PTP1B inactivation by ROS and decreased EGFR phosphorylation. Our data suggest that destabi...

Descripción completa

Detalles Bibliográficos
Autores principales: Londhe, Avinash D., Bergeron, Alexandre, Curley, Stephanie M., Zhang, Fuming, Rivera, Keith D., Kannan, Akaash, Coulis, Gérald, Rizvi, Syed H. M., Kim, Seung Jun, Pappin, Darryl J., Tonks, Nicholas K., Linhardt, Robert J., Boivin, Benoit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982540/
https://www.ncbi.nlm.nih.gov/pubmed/31873221
http://dx.doi.org/10.1038/s41589-019-0433-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982540/
https://www.ncbi.nlm.nih.gov/pubmed/31873221
http://dx.doi.org/10.1038/s41589-019-0433-0

Ejemplares similares