Extensive Structure Modification on Luteolin-Cinnamic Acid Conjugates Leading to BACE1 Inhibitors with Optimal Pharmacological Properties

BACE1 inhibitory conjugates derived from two natural products, luteolin (1) and p-hydroxy-cinnamic acid (2), were subjected to systematic structure modifications, including various positions in luteolin segment for conjugation, different linkers (length, bond variation), as well as various substitut...

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Detalles Bibliográficos
Autores principales: Sun, De-Yang, Cheng, Chen, Moschke, Katrin, Huang, Jian, Fang, Wei-Shuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982702/
https://www.ncbi.nlm.nih.gov/pubmed/31888099
http://dx.doi.org/10.3390/molecules25010102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982702/
https://www.ncbi.nlm.nih.gov/pubmed/31888099
http://dx.doi.org/10.3390/molecules25010102

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