Specificity Assessment of CRISPR Genome Editing of Oncogenic EGFR Point Mutation with Single-Base Differences

In CRISPR genome editing, CRISPR proteins form ribonucleoprotein complexes with guide RNAs to bind and cleave the target DNAs with complete sequence complementarity. CRISPR genome editing has a high potential for use in precision gene therapy for various diseases, including cancer and genetic disord...

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Detalles Bibliográficos
Autores principales: Bae, Taegeun, Kim, Hanseop, Kim, Jeong Hee, Kim, Yong Jun, Lee, Seung Hwan, Ham, Byung-Joo, Hur, Junho K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982904/
https://www.ncbi.nlm.nih.gov/pubmed/31877894
http://dx.doi.org/10.3390/molecules25010052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982904/
https://www.ncbi.nlm.nih.gov/pubmed/31877894
http://dx.doi.org/10.3390/molecules25010052

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