Structure-Based Virtual Screening and Biological Evaluation of Peptide Inhibitors for Polo-Box Domain

The polo-box domain of polo-like kinase 1 (PLK1-PBD) is proved to have crucial roles in cell proliferation. Designing PLK1-PBD inhibitors is challenging due to their poor cellular penetration. In this study, we applied a virtual screening workflow based on a combination of structure-based pharmacoph...

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Detalles Bibliográficos
Autores principales: Yan, Fang, Liu, Guangmei, Chen, Tingting, Fu, Xiaochen, Niu, Miao-Miao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982974/
https://www.ncbi.nlm.nih.gov/pubmed/31892137
http://dx.doi.org/10.3390/molecules25010107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982974/
https://www.ncbi.nlm.nih.gov/pubmed/31892137
http://dx.doi.org/10.3390/molecules25010107

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