Oral lesions in patients with primary Sjögren’s syndrome. A case-control cross-sectional study

BACKGROUND: To evaluate the presence of oral lesions in a group of patients with primary Sjögren’s syndrome (pSS) and compare these results with a matched control group (CG). MATERIAL AND METHODS: An observational cross-sectional study was conducted. 61 pSS patients (60 women, 1 man, mean age 57.64±...

Descripción completa

Detalles Bibliográficos
Autores principales: Serrano, Julia, López-Pintor, Rosa María, Fernández-Castro, Mónica, Ramírez, Lucía, Sanz, Mariano, Casañas, Elisabeth, García, Jesús Alberto, Recuero, Sheila, Bohorquez, Cristina, Hernández, Gonzalo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medicina Oral S.L. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982992/
https://www.ncbi.nlm.nih.gov/pubmed/31880282
http://dx.doi.org/10.4317/medoral.23254
_version_ 1783491416929861632
author Serrano, Julia
López-Pintor, Rosa María
Fernández-Castro, Mónica
Ramírez, Lucía
Sanz, Mariano
Casañas, Elisabeth
García, Jesús Alberto
Recuero, Sheila
Bohorquez, Cristina
Hernández, Gonzalo
author_facet Serrano, Julia
López-Pintor, Rosa María
Fernández-Castro, Mónica
Ramírez, Lucía
Sanz, Mariano
Casañas, Elisabeth
García, Jesús Alberto
Recuero, Sheila
Bohorquez, Cristina
Hernández, Gonzalo
author_sort Serrano, Julia
collection PubMed
description BACKGROUND: To evaluate the presence of oral lesions in a group of patients with primary Sjögren’s syndrome (pSS) and compare these results with a matched control group (CG). MATERIAL AND METHODS: An observational cross-sectional study was conducted. 61 pSS patients (60 women, 1 man, mean age 57.64±13.52) diagnosed according to the American European Criteria (2002), and 122 matched control patients (120 women, 2 men, mean age 60.02±13.13) were included. Demographic and medical data, oral lesions and salivary flow rate were collected. RESULTS: Compared with the controls, pSS patients were 3.95 more likely to have oral lesions (OR 3.95; 95% CI 2.06-7.58; p=0.0001). 57.4% pSS patients presented oral lesions compared to 25.4% in CG. The most common were candidiasis (13.1% vs 2.5%), traumatic lesions (13.1% vs 4.1%), apthae (8.2% vs 0), and fissuration of the tongue (8.2% vs 0.8%). pSS patients with oral lesions had lower salivary flow levels (stimulated and unstimulated), although these differences were not significant. Significant associations were found between the presence of oral lesions and systemic manifestations and history of parotid gland enlargement in pSS patients. CONCLUSIONS: pSS patients suffer more oral lesions than general population and these lesions may aggravate the pSS disease. Key words:Sjögren’s syndrome, oral lesions, oral diseases, oral manifestations, oral disorders.
format Online
Article
Text
id pubmed-6982992
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Medicina Oral S.L.
record_format MEDLINE/PubMed
spelling pubmed-69829922020-01-29 Oral lesions in patients with primary Sjögren’s syndrome. A case-control cross-sectional study Serrano, Julia López-Pintor, Rosa María Fernández-Castro, Mónica Ramírez, Lucía Sanz, Mariano Casañas, Elisabeth García, Jesús Alberto Recuero, Sheila Bohorquez, Cristina Hernández, Gonzalo Med Oral Patol Oral Cir Bucal Research BACKGROUND: To evaluate the presence of oral lesions in a group of patients with primary Sjögren’s syndrome (pSS) and compare these results with a matched control group (CG). MATERIAL AND METHODS: An observational cross-sectional study was conducted. 61 pSS patients (60 women, 1 man, mean age 57.64±13.52) diagnosed according to the American European Criteria (2002), and 122 matched control patients (120 women, 2 men, mean age 60.02±13.13) were included. Demographic and medical data, oral lesions and salivary flow rate were collected. RESULTS: Compared with the controls, pSS patients were 3.95 more likely to have oral lesions (OR 3.95; 95% CI 2.06-7.58; p=0.0001). 57.4% pSS patients presented oral lesions compared to 25.4% in CG. The most common were candidiasis (13.1% vs 2.5%), traumatic lesions (13.1% vs 4.1%), apthae (8.2% vs 0), and fissuration of the tongue (8.2% vs 0.8%). pSS patients with oral lesions had lower salivary flow levels (stimulated and unstimulated), although these differences were not significant. Significant associations were found between the presence of oral lesions and systemic manifestations and history of parotid gland enlargement in pSS patients. CONCLUSIONS: pSS patients suffer more oral lesions than general population and these lesions may aggravate the pSS disease. Key words:Sjögren’s syndrome, oral lesions, oral diseases, oral manifestations, oral disorders. Medicina Oral S.L. 2020-01 2019-12-24 /pmc/articles/PMC6982992/ /pubmed/31880282 http://dx.doi.org/10.4317/medoral.23254 Text en Copyright: © 2020 Medicina Oral S.L. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Serrano, Julia
López-Pintor, Rosa María
Fernández-Castro, Mónica
Ramírez, Lucía
Sanz, Mariano
Casañas, Elisabeth
García, Jesús Alberto
Recuero, Sheila
Bohorquez, Cristina
Hernández, Gonzalo
Oral lesions in patients with primary Sjögren’s syndrome. A case-control cross-sectional study
title Oral lesions in patients with primary Sjögren’s syndrome. A case-control cross-sectional study
title_full Oral lesions in patients with primary Sjögren’s syndrome. A case-control cross-sectional study
title_fullStr Oral lesions in patients with primary Sjögren’s syndrome. A case-control cross-sectional study
title_full_unstemmed Oral lesions in patients with primary Sjögren’s syndrome. A case-control cross-sectional study
title_short Oral lesions in patients with primary Sjögren’s syndrome. A case-control cross-sectional study
title_sort oral lesions in patients with primary sjögren’s syndrome. a case-control cross-sectional study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982992/
https://www.ncbi.nlm.nih.gov/pubmed/31880282
http://dx.doi.org/10.4317/medoral.23254
work_keys_str_mv AT serranojulia orallesionsinpatientswithprimarysjogrenssyndromeacasecontrolcrosssectionalstudy
AT lopezpintorrosamaria orallesionsinpatientswithprimarysjogrenssyndromeacasecontrolcrosssectionalstudy
AT fernandezcastromonica orallesionsinpatientswithprimarysjogrenssyndromeacasecontrolcrosssectionalstudy
AT ramirezlucia orallesionsinpatientswithprimarysjogrenssyndromeacasecontrolcrosssectionalstudy
AT sanzmariano orallesionsinpatientswithprimarysjogrenssyndromeacasecontrolcrosssectionalstudy
AT casanaselisabeth orallesionsinpatientswithprimarysjogrenssyndromeacasecontrolcrosssectionalstudy
AT garciajesusalberto orallesionsinpatientswithprimarysjogrenssyndromeacasecontrolcrosssectionalstudy
AT recuerosheila orallesionsinpatientswithprimarysjogrenssyndromeacasecontrolcrosssectionalstudy
AT bohorquezcristina orallesionsinpatientswithprimarysjogrenssyndromeacasecontrolcrosssectionalstudy
AT hernandezgonzalo orallesionsinpatientswithprimarysjogrenssyndromeacasecontrolcrosssectionalstudy