Trimethoprim: An Old Antibacterial Drug as a Template to Search for New Targets. Synthesis, Biological Activity and Molecular Modeling Study of Novel Trimethoprim Analogs

A new series of trimethoprim (TMP) analogs containing amide bonds (1–6) have been synthesized. Molecular docking, as well as dihydrofolate reductase (DHFR) inhibition assay were used to confirm their affinity to bind dihydrofolate reductase enzyme. Data from the ethidium displacement test showed the...

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Detalles Bibliográficos
Autores principales: Wróbel, Agnieszka, Maliszewski, Dawid, Baradyn, Maciej, Drozdowska, Danuta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983048/
https://www.ncbi.nlm.nih.gov/pubmed/31892256
http://dx.doi.org/10.3390/molecules25010116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983048/
https://www.ncbi.nlm.nih.gov/pubmed/31892256
http://dx.doi.org/10.3390/molecules25010116

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