Cargando…

A Suitable Functionalization of Nitroindazoles with Triazolyl and Pyrazolyl Moieties via Cycloaddition Reactions

The alkylation of a series of nitroindazole derivatives with 1,2-dibromoethane afforded the corresponding N-(2-bromoethyl)- and N-vinyl-nitro-1H-indazoles. The Cu(I)-catalysed azide- alkyne 1,3-dipolar cycloaddition was selected to substitute the nitroindazole core with 1,4-disubstituted triazole un...

Descripción completa

Detalles Bibliográficos
Autores principales:	Eddahmi, Mohammed, Moura, Nuno M. M., Bouissane, Latifa, Amiri, Ouafa, Faustino, M. Amparo F., Cavaleiro, José A. S., Mendes, Ricardo F., Paz, Filipe A. A., Neves, Maria G. P. M. S., Rakib, El Mostapha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983193/ https://www.ncbi.nlm.nih.gov/pubmed/31905680 http://dx.doi.org/10.3390/molecules25010126

Ejemplares similares

Design, Synthesis, and Biological Activities of Novel 2-Cyanoacrylate Compounds Containing Substituted Pyrazolyl or 1,2,3-Triazolyl Moiety
por: Wang, Yang, et al.
Publicado: (2023)

N-(1-Allyl-3-chloro-4-ethoxy-1H-indazol-5-yl)-4-methylbenzenesulfonamide
por: Chicha, Hakima, et al.
Publicado: (2014)

Crystal structure of N-(1-allyl-3-chloro-4-ethoxy-1H-indazol-5-yl)-4-methoxybenzenesulfonamide
por: Chicha, Hakima, et al.
Publicado: (2014)

N-(1H-Indazol-5-yl)-4-methoxybenzenesulfonamide
por: Chicha, Hakima, et al.
Publicado: (2013)

N-(3-Chloro-1H-indazol-5-yl)-4-methoxybenzenesulfonamide
por: Chicha, Hakima, et al.
Publicado: (2013)

Antileishmanial activity of 5-nitroindazole derivatives
por: Mollineda-Diogo, Niurka, et al.
Publicado: (2023)

N-(2-Allyl-4-ethoxy-2H-indazol-5-yl)-4-methylbenzenesulfonamide. Corrigendum
por: Chicha, Hakima, et al.
Publicado: (2014)

N-(2-Allyl-4-ethoxy-2H-indazol-5-yl)-4-methylbenzenesulfonamide
por: Chicha, Hakima, et al.
Publicado: (2014)

Synthesis and Characterization of Some New Bis-Pyrazolyl-Thiazoles Incorporating the Thiophene Moiety as Potent Anti-Tumor Agents
por: Gomha, Sobhi M., et al.
Publicado: (2016)

Diastereoselective synthesis of atropisomeric pyrazolyl pyrrolo[3,4-d]isoxazolidines via pyrazolyl nitrone cycloaddition to facially divergent maleimides: intensive NMR and DFT studies
por: Said, Awad I., et al.
Publicado: (2020)

N-(3-Chloro-1-methyl-1H-indazol-5-yl)-4-methylbenzenesulfonamide
por: Chicha, Hakima, et al.
Publicado: (2014)

Crystal structure of 2-(4-methylbenzylidene)malononitrile
por: Amiri, Ouafa, et al.
Publicado: (2014)

Asymmetric rhodium-catalyzed click cycloaddition to access C–N axially chiral N-triazolyl indoles
por: Zhou, Li, et al.
Publicado: (2023)

Regioselective Synthesis of NO-Donor (4-Nitro-1,2,3-triazolyl)furoxans via Eliminative Azide–Olefin Cycloaddition
por: Stebletsova, Irina A., et al.
Publicado: (2023)

7-Nitroindazole reduces L-DOPA-induced dyskinesias in non-human Parkinsonian primate
por: Herrero, M. T., et al.
Publicado: (2023)

The First 5′-Phosphorylated 1,2,3-Triazolyl Nucleoside Analogues with Uracil and Quinazoline-2,4-Dione Moieties: A Synthesis and Antiviral Evaluation
por: Tatarinov, Dmitry A., et al.
Publicado: (2022)

Synthesis and Biological Evaluation of N- Pyrazolyl Derivatives and Pyrazolopyrimidine Bearing a Biologically Active Sulfonamide Moiety as Potential Antimicrobial Agent
por: Hafez, Hend N., et al.
Publicado: (2016)

7-Nitroindazole and its rapidly emerging role in opioid pain management and withdrawal
por: Kapoor, Shailendra
Publicado: (2012)

Terminal and Internal Alkyne Complexes and Azide-Alkyne Cycloaddition Chemistry of Copper(I) Supported by a Fluorinated Bis(pyrazolyl)borate
por: Noonikara-Poyil, Anurag, et al.
Publicado: (2021)

Design, Synthesis and Bioactivities of Novel 1,4-Pentadien-3-one Derivatives Containing a Substituted Pyrazolyl Moiety
por: Chen, Cuili, et al.
Publicado: (2017)

Synthesis of 1,2,3-triazolyl nucleoside analogues and their antiviral activity
por: Andreeva, Olga V., et al.
Publicado: (2020)

Biological evaluation of pyrazolyl-urea and dihydro-imidazo-pyrazolyl-urea derivatives as potential anti-angiogenetic agents in the treatment of neuroblastoma
por: Marengo, Barbara, et al.
Publicado: (2020)

Pyrazolyl-Ureas as Interesting Scaffold in Medicinal Chemistry
por: Brullo, Chiara, et al.
Publicado: (2020)

Correction: Biological evaluation of pyrazolyl-urea and dihydro-imidazo-pyrazolyl-urea derivatives as potential anti-angiogenetic agents in the treatment of neuroblastoma
por: Marengo, Barbara, et al.
Publicado: (2023)

Synthesis and Evaluations of “1,4‐Triazolyl Combretacoumarins” and Desmethoxy Analogs
por: Khandaker, Tashrique A., et al.
Publicado: (2019)

Antimalarial Activity of C-10 Substituted Triazolyl Artemisinin
por: Park, Gab-Man, et al.
Publicado: (2017)

Click Chemistry Inspired Synthesis of Hydroxyanthracene Triazolyl Glycoconjugates
por: Pandey, Nishant, et al.
Publicado: (2022)

Inhibiting EGFR Dimerization Using Triazolyl-Bridged Dimerization Arm Mimics
por: Hanold, Laura E., et al.
Publicado: (2015)

Selective Nitric Oxide Synthase Inhibitor 7-Nitroindazole Protects against Cocaine-Induced Oxidative Stress in Rat Brain
por: Vitcheva, Vessela, et al.
Publicado: (2015)

Challenging inflammatory process at molecular, cellular and in vivo levels via some new pyrazolyl thiazolones
por: Elzahhar, Perihan A., et al.
Publicado: (2021)

Synthesis and antiproliferative assay of triazolyl-2,2-dimethyl-3-phenylpropanoates as potential HDAC inhibitors
por: El-Rayes, Samir, et al.
Publicado: (2019)

Design, Synthesis, and Anti-Bacterial Evaluation of Triazolyl-Pterostilbene Derivatives
por: Tang, Kai-Wei, et al.
Publicado: (2019)

The Effects of (11R)-13-(6-Nitroindazole)-11,13-Dihydroludartin on Human Prostate Carcinoma Cells and Mouse Tumor Xenografts
por: Wang, Longning, et al.
Publicado: (2020)

Synthesis of Known and Previously Inaccessible Poly(pyrazolyl)Borates under Mild Conditions
por: Melero, María M., et al.
Publicado: (2023)

Pyrazolyl Thioureas and Carbothioamides with an NNSN Motif against MSSA and MRSA
por: Delpe-Acharige, Anjana, et al.
Publicado: (2021)

Bis(2,6-pyrazolyl)pyridines as a New Scaffold for Coordination Polymers
por: Nikovskiy, Igor A., et al.
Publicado: (2023)

Synthesis and Biological Evaluation of Triazolyl 13α-Estrone–Nucleoside Bioconjugates
por: Bodnár, Brigitta, et al.
Publicado: (2016)

Impact of Tralopyril and Triazolyl Glycosylated Chalcone in Human Retinal Cells’ Lipidome
por: Vilas-Boas, Cátia, et al.
Publicado: (2022)

Synthesis of New Bitopic Tetra(pyrazolyl)-Ligands with Neopentane and O-Xylene Backbones
por: Potapov, Andrei S., et al.
Publicado: (2012)

The effects of 7-nitroindazole on serum neuron-specific enolase and astroglia-derived protein (S100β) levels after traumatic brain injury
por: Dong, Nan, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_16ab2rjaputlfglr6fiorpebpl