A Triazole Hybrid of Neolignans as a Potential Antileishmanial Agent by Triggering Mitochondrial Dysfunction

In the search for new compounds with antileishmanial activity, we synthesized a triazole hybrid analogue of the neolignans grandisin and machilin G (LASQUIM 25), which was previously found highly active against both promastigotes and intracellular amastigote forms of Leishmania amazonensis. In this...

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Detalles Bibliográficos
Autores principales: Cardozo Pinto de Arruda, Carla, de Jesus Hardoim, Daiana, Silva Rizk, Yasmin, da Silva Freitas de Souza, Celeste, Zaverucha do Valle, Tânia, Bento Carvalho, Diego, Nosomi Taniwaki, Noemi, de Morais Baroni, Adriano Cesar, da Silva Calabrese, Kátia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983227/
https://www.ncbi.nlm.nih.gov/pubmed/31861910
http://dx.doi.org/10.3390/molecules25010037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983227/
https://www.ncbi.nlm.nih.gov/pubmed/31861910
http://dx.doi.org/10.3390/molecules25010037

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