Structural Bases for the Fitness Cost of the Antibiotic-Resistance and Lethal Mutations at Position 1408 of 16S rRNA

To understand a structural basis for the fitness cost of the A1408G antibiotic-resistance mutation in the ribosomal A-site RNA, we have determined crystal structures of its A1408C and A1408U lethal mutants, and made comparison with previously solved structures of the wild type and the antibiotic-res...

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Detalles Bibliográficos
Autores principales: Kondo, Jiro, Koganei, Mai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983231/
https://www.ncbi.nlm.nih.gov/pubmed/31906077
http://dx.doi.org/10.3390/molecules25010159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983231/
https://www.ncbi.nlm.nih.gov/pubmed/31906077
http://dx.doi.org/10.3390/molecules25010159

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