Homeostatic regulation of STING protein at the resting-state by stabilizer TOLLIP

STING is an important innate immune protein, but its homeostatic regulation at the resting-state is unknown. Here, we identified TOLLIP as a stabilizer of STING through direct interaction to prevent its degradation. Tollip-deficiency results in reduced resting-state STING protein level in nonhematop...

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Detalles Bibliográficos
Autores principales: Pokatayev, Vladislav, Yang, Kun, Tu, Xintao, Dobbs, Nicole, Wu, Jianjun, Kalb, Robert G., Yan, Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983345/
https://www.ncbi.nlm.nih.gov/pubmed/31932809
http://dx.doi.org/10.1038/s41590-019-0569-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983345/
https://www.ncbi.nlm.nih.gov/pubmed/31932809
http://dx.doi.org/10.1038/s41590-019-0569-9

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