Cargando…

Quantitative microscopy reveals dynamics and fate of clustered IRE1α

The endoplasmic reticulum (ER) membrane-resident stress sensor inositol-requiring enzyme 1 (IRE1) governs the most evolutionarily conserved branch of the unfolded protein response. Upon sensing an accumulation of unfolded proteins in the ER lumen, IRE1 activates its cytoplasmic kinase and ribonuclea...

Descripción completa

Detalles Bibliográficos
Autores principales:	Belyy, Vladislav, Tran, Ngoc-Han, Walter, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2020
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983381/ https://www.ncbi.nlm.nih.gov/pubmed/31871156 http://dx.doi.org/10.1073/pnas.1915311117

Ejemplares similares

Endoplasmic reticulum stress activates human IRE1α through reversible assembly of inactive dimers into small oligomers
por: Belyy, Vladislav, et al.
Publicado: (2022)

Computationally enhanced quantitative phase microscopy reveals autonomous oscillations in mammalian cell growth
por: Liu, Xili, et al.
Publicado: (2020)

Conserved structural elements specialize ATAD1 as a membrane protein extraction machine
por: Wang, Lan, et al.
Publicado: (2022)

Atomic force microscopy reveals distinct protofilament-scale structural dynamics in depolymerizing microtubule arrays
por: Wijeratne, Sithara S., et al.
Publicado: (2022)

Integrated spatial multiomics reveals fibroblast fate during tissue repair
por: Foster, Deshka S., et al.
Publicado: (2021)

Disruption of proteostasis causes IRE1 mediated reprogramming of alveolar epithelial cells
por: Katzen, Jeremy, et al.
Publicado: (2022)

Advanced fluorescence microscopy reveals disruption of dynamic CXCR4 dimerization by subpocket-specific inverse agonists
por: Işbilir, Ali, et al.
Publicado: (2020)

State- and stimulus-specific dynamics of SMAD signaling determine fate decisions in individual cells
por: Bohn, Stefan, et al.
Publicado: (2023)

Ovarian cancer cell fate regulation by the dynamics between saturated and unsaturated fatty acids
por: Zhao, Guangyuan, et al.
Publicado: (2022)

Mechanosensitive stem cell fate choice is instructed by dynamic fluctuations in activation of Rho GTPases
por: Sampayo, Rocío G., et al.
Publicado: (2023)

Optimal inference of molecular interaction dynamics in FRET microscopy
por: Kamino, Keita, et al.
Publicado: (2023)

Bip-Yorkie interaction determines oncogenic and tumor-suppressive roles of Ire1/Xbp1s activation
por: Yang, Shuai, et al.
Publicado: (2022)

Visualizing active viral infection reveals diverse cell fates in synchronized algal bloom demise
por: Vincent, Flora, et al.
Publicado: (2021)

EMBER multidimensional spectral microscopy enables quantitative determination of disease- and cell-specific amyloid strains
por: Yang, Hyunjun, et al.
Publicado: (2023)

The Sec61 translocon limits IRE1α signaling during the unfolded protein response
por: Sundaram, Arunkumar, et al.
Publicado: (2017)

The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1
por: Acosta-Alvear, Diego, et al.
Publicado: (2018)

Formation of clustered DNA damage in vivo upon irradiation with ionizing radiation: Visualization and analysis with atomic force microscopy
por: Nakano, Toshiaki, et al.
Publicado: (2022)

A novel regulatory gene promotes novel cell fate by suppressing ancestral fate in the sea anemone Nematostella vectensis
por: Babonis, Leslie S., et al.
Publicado: (2022)

Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clustering
por: Lai, Ying, et al.
Publicado: (2023)

IRE1 signaling regulates chondrocyte apoptosis and death fate in the osteoarthritis
por: Huang, Rongxiang, et al.
Publicado: (2021)

An unfolded protein-induced conformational switch activates mammalian IRE1
por: Karagöz, G Elif, et al.
Publicado: (2017)

The IRES(5′UTR) of the dicistrovirus cricket paralysis virus is a type III IRES containing an essential pseudoknot structure
por: Gross, Lauriane, et al.
Publicado: (2017)

Three genomes in the algal genus Volvox reveal the fate of a haploid sex-determining region after a transition to homothallism
por: Yamamoto, Kayoko, et al.
Publicado: (2021)

Inhibiting IRE1α-endonuclease activity decreases tumor burden in a mouse model for hepatocellular carcinoma
por: Pavlović, Nataša, et al.
Publicado: (2020)

Cardiac progenitors instruct second heart field fate through Wnts
por: Miyamoto, Matthew, et al.
Publicado: (2023)

Antiparallel dimer structure of CELSR cadherin in solution revealed by high-speed-atomic force microscopy
por: Nishiguchi, Shigetaka, et al.
Publicado: (2023)

Deep-learning microscopy image reconstruction with quality control reveals second-scale rearrangements in RNA polymerase II clusters
por: Hajiabadi, Hamideh, et al.
Publicado: (2022)

Spatiotemporal dynamics of calcium signals during neutrophil cluster formation
por: Khazen, Roxana, et al.
Publicado: (2022)

Protomer alignment modulates specificity of RNA substrate recognition by Ire1
por: Li, Weihan, et al.
Publicado: (2021)

The Structure, Activation and Signaling of IRE1 and Its Role in Determining Cell Fate
por: Siwecka, Natalia, et al.
Publicado: (2021)

Fate plasticity and reprogramming in genetically distinct populations of Danio leucophores
por: Lewis, Victor M., et al.
Publicado: (2019)

Genes and evolutionary fates of the amanitin biosynthesis pathway in poisonous mushrooms
por: Luo, Hong, et al.
Publicado: (2022)

hnRNP Q and PTB modulate the circadian oscillation of mouse Rev-erb α via IRES-mediated translation
por: Kim, Do-Yeon, et al.
Publicado: (2010)

Unstructured regions in IRE1α specify BiP-mediated destabilisation of the luminal domain dimer and repression of the UPR
por: Amin-Wetzel, Niko, et al.
Publicado: (2019)

High-speed atomic force microscopy reveals a three-state elevator mechanism in the citrate transporter CitS
por: Maity, Sourav, et al.
Publicado: (2022)

Autocrine regulation of mesenchymal progenitor cell fates orchestrates tooth eruption
por: Takahashi, Akira, et al.
Publicado: (2019)

Palmitoylation of BMPR1a regulates neural stem cell fate
por: Wegleiter, Thomas, et al.
Publicado: (2019)

MSX2 safeguards syncytiotrophoblast fate of human trophoblast stem cells
por: Hornbachner, Ruth, et al.
Publicado: (2021)

Heritable changes in division speed accompany the diversification of single T cell fate
por: Plambeck, Marten, et al.
Publicado: (2022)

Thalamocortical axons regulate neurogenesis and laminar fates in the early sensory cortex
por: Monko, Timothy, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_30cnnp3vq7aa64hv0jtsh76r3r