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Long-range interdomain communications in eIF5B regulate GTP hydrolysis and translation initiation
Translation initiation controls protein synthesis by regulating the delivery of the first aminoacyl-tRNA to messenger RNAs (mRNAs). In eukaryotes, initiation is sophisticated, requiring dozens of protein factors and 2 GTP-regulated steps. The GTPase eIF5B gates progression to elongation during the s...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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National Academy of Sciences
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983393/ https://www.ncbi.nlm.nih.gov/pubmed/31900355 http://dx.doi.org/10.1073/pnas.1916436117 |