A compartment size-dependent selective threshold limits mutation accumulation in hierarchical tissues

Cancer is a genetic disease fueled by somatic evolution. Hierarchical tissue organization can slow somatic evolution by two qualitatively different mechanisms: by cell differentiation along the hierarchy “washing out” harmful mutations and by limiting the number of cell divisions required to maintai...

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Detalles Bibliográficos
Autores principales: Grajzel, Dániel, Derényi, Imre, Szöllősi, Gergely J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983402/
https://www.ncbi.nlm.nih.gov/pubmed/31907322
http://dx.doi.org/10.1073/pnas.1913104117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983402/
https://www.ncbi.nlm.nih.gov/pubmed/31907322
http://dx.doi.org/10.1073/pnas.1913104117

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