High-dose ascorbic acid synergizes with anti-PD1 in a lymphoma mouse model

Major efforts are underway to identify agents that can potentiate effects of immune checkpoint inhibition. Here, we show that ascorbic acid (AA) treatment caused genomewide demethylation and enhanced expression of endogenous retroviral elements in lymphoma cells. AA also increased 5-hydroxymethylcyt...

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Detalles Bibliográficos
Autores principales: Luchtel, Rebecca A., Bhagat, Tushar, Pradhan, Kith, Jacobs, William R., Levine, Mark, Verma, Amit, Shenoy, Niraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983418/
https://www.ncbi.nlm.nih.gov/pubmed/31911474
http://dx.doi.org/10.1073/pnas.1908158117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983418/
https://www.ncbi.nlm.nih.gov/pubmed/31911474
http://dx.doi.org/10.1073/pnas.1908158117

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