A unique B cell epitope-based particulate vaccine shows effective suppression of hepatitis B surface antigen in mice

OBJECTIVE: This study aimed to develop a novel therapeutic vaccine based on a unique B cell epitope and investigate its therapeutic potential against chronic hepatitis B (CHB) in animal models. METHODS: A series of peptides and carrier proteins were evaluated in HBV-tolerant mice to obtain an optimi...

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Detalles Bibliográficos
Autores principales: Zhang, Tian-Ying, Guo, Xue-Ran, Wu, Yang-Tao, Kang, Xiao-Zhen, Zheng, Qing-Bing, Qi, Ruo-Yao, Chen, Bin-Bing, Lan, Ying, Wei, Min, Wang, Shao-Juan, Xiong, Hua-Long, Cao, Jia-Li, Zhang, Bao-Hui, Qiao, Xiao-Yang, Huang, Xiao-Fen, Wang, Ying-Bin, Fang, Mu-Jin, Zhang, Ya-Li, Cheng, Tong, Chen, Yi-Xin, Zhao, Qin-Jian, Li, Shao-Wei, Ge, Sheng-Xiang, Chen, Pei-Jer, Zhang, Jun, Yuan, Quan, Xia, Ning-shao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Hepatology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984059/
https://www.ncbi.nlm.nih.gov/pubmed/30926653
http://dx.doi.org/10.1136/gutjnl-2018-317725

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984059/
https://www.ncbi.nlm.nih.gov/pubmed/30926653
http://dx.doi.org/10.1136/gutjnl-2018-317725

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