Targeting the Mycobacterium tuberculosis transpeptidase Ldt(Mt2) with cysteine-reactive inhibitors including ebselen

The l,d-transpeptidases (Ldts) are promising antibiotic targets for treating tuberculosis. We report screening of cysteine-reactive inhibitors against Ldt(Mt2) from Mycobacterium tuberculosis. Structural studies on Ldt(Mt2) with potent inhibitor ebselen reveal opening of the benzisoselenazolone ring...

Descripción completa

Detalles Bibliográficos
Autores principales: de Munnik, Mariska, Lohans, Christopher T., Lang, Pauline A., Langley, Gareth W., Malla, Tika R., Tumber, Anthony, Schofield, Christopher J., Brem, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984337/
https://www.ncbi.nlm.nih.gov/pubmed/31380528
http://dx.doi.org/10.1039/c9cc04145a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984337/
https://www.ncbi.nlm.nih.gov/pubmed/31380528
http://dx.doi.org/10.1039/c9cc04145a

Ejemplares similares