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Targeting the Mycobacterium tuberculosis transpeptidase Ldt(Mt2) with cysteine-reactive inhibitors including ebselen

The l,d-transpeptidases (Ldts) are promising antibiotic targets for treating tuberculosis. We report screening of cysteine-reactive inhibitors against Ldt(Mt2) from Mycobacterium tuberculosis. Structural studies on Ldt(Mt2) with potent inhibitor ebselen reveal opening of the benzisoselenazolone ring...

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Detalles Bibliográficos
Autores principales:	de Munnik, Mariska, Lohans, Christopher T., Lang, Pauline A., Langley, Gareth W., Malla, Tika R., Tumber, Anthony, Schofield, Christopher J., Brem, Jürgen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984337/ https://www.ncbi.nlm.nih.gov/pubmed/31380528 http://dx.doi.org/10.1039/c9cc04145a

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