Stochastic Gene Expression Influences the Selection of Antibiotic Resistance Mutations

Bacteria can resist antibiotics by expressing enzymes that remove or deactivate drug molecules. Here, we study the effects of gene expression stochasticity on efflux and enzymatic resistance. We construct an agent-based model that stochastically simulates multiple biochemical processes in the cell a...

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Detalles Bibliográficos
Autores principales: Sun, Lei, Ashcroft, Peter, Ackermann, Martin, Bonhoeffer, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984361/
https://www.ncbi.nlm.nih.gov/pubmed/31504754
http://dx.doi.org/10.1093/molbev/msz199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984361/
https://www.ncbi.nlm.nih.gov/pubmed/31504754
http://dx.doi.org/10.1093/molbev/msz199

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