Cargando…

Stochastic Gene Expression Influences the Selection of Antibiotic Resistance Mutations

Bacteria can resist antibiotics by expressing enzymes that remove or deactivate drug molecules. Here, we study the effects of gene expression stochasticity on efflux and enzymatic resistance. We construct an agent-based model that stochastically simulates multiple biochemical processes in the cell a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, Lei, Ashcroft, Peter, Ackermann, Martin, Bonhoeffer, Sebastian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Discoveries
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984361/ https://www.ncbi.nlm.nih.gov/pubmed/31504754 http://dx.doi.org/10.1093/molbev/msz199

Ejemplares similares

Population Heterogeneity in Mutation Rate Increases the Frequency of Higher-Order Mutants and Reduces Long-Term Mutational Load
por: Alexander, Helen K., et al.
Publicado: (2017)

Pervasive Selection for Clinically Relevant Resistance and Media Adaptive Mutations at Very Low Antibiotic Concentrations
por: Pereira, Catia, et al.
Publicado: (2023)

Nonoptimal Gene Expression Creates Latent Potential for Antibiotic Resistance
por: Palmer, Adam C, et al.
Publicado: (2018)

Chance Favors the Prepared Genomes: Horizontal Transfer Shapes the Emergence of Antibiotic Resistance Mutations in Core Genes
por: Coluzzi, Charles, et al.
Publicado: (2023)

Epistasis and Pleiotropy Affect the Modularity of the Genotype–Phenotype Map of Cross-Resistance in HIV-1
por: Polster, Robert, et al.
Publicado: (2016)

Herbicide Selection Promotes Antibiotic Resistance in Soil Microbiomes
por: Liao, Hanpeng, et al.
Publicado: (2021)

Evolutionary History and Strength of Selection Determine the Rate of Antibiotic Resistance Adaptation
por: Cisneros-Mayoral, Sandra, et al.
Publicado: (2022)

Strength of Selection Pressure Is an Important Parameter Contributing to the Complexity of Antibiotic Resistance Evolution
por: Oz, Tugce, et al.
Publicado: (2014)

The Fitness Effects of Codon Composition of the Horizontally Transferred Antibiotic Resistance Genes Intensify at Sub-lethal Antibiotic Levels
por: Shaferman, Michael, et al.
Publicado: (2023)

The Antibiotic Dosage of Fastest Resistance Evolution: Gene Amplifications Underpinning the Inverted-U
por: Reding, Carlos, et al.
Publicado: (2021)

Transcription-Associated Mutation Promotes RNA Complexity in Highly Expressed Genes—A Major New Source of Selectable Variation
por: Pan, Shengkai, et al.
Publicado: (2018)

Positive Selection Underlies Faster-Z Evolution of Gene Expression in Birds
por: Dean, Rebecca, et al.
Publicado: (2015)

Using Selection by Nonantibiotic Stressors to Sensitize Bacteria to Antibiotics
por: Maltas, Jeff, et al.
Publicado: (2020)

Enhanced Mutation Rate, Relaxed Selection, and the “Domino Effect” are associated with Gene Loss in Blattabacterium, A Cockroach Endosymbiont
por: Kinjo, Yukihiro, et al.
Publicado: (2021)

Horizontal Gene Transfer, Fitness Costs and Mobility Shape the Spread of Antibiotic Resistance Genes into Experimental Populations of Acinetobacter Baylyi
por: Sezmis, Aysha L, et al.
Publicado: (2023)

DNA Breaks-Mediated Fitness Cost Reveals RNase HI as a New Target for Selectively Eliminating Antibiotic-Resistant Bacteria
por: Balbontín, Roberto, et al.
Publicado: (2021)

Excess of Deleterious Mutations around HLA Genes Reveals Evolutionary Cost of Balancing Selection
por: Lenz, Tobias L., et al.
Publicado: (2016)

Deleterious Mutations and the Rare Allele Burden on Rice Gene Expression
por: Lye, Zoe, et al.
Publicado: (2022)

Paternally Expressed Imprinted Genes under Positive Darwinian Selection in Arabidopsis thaliana
por: Tuteja, Reetu, et al.
Publicado: (2019)

Biased Mutation and Selection in RNA Viruses
por: Kustin, Talia, et al.
Publicado: (2020)

Developmental Selection and the Perception of Mutation Bias
por: Majic, Paco, et al.
Publicado: (2023)

Perturbation of Iron Homeostasis Promotes the Evolution of Antibiotic Resistance
por: Méhi, Orsolya, et al.
Publicado: (2014)

Multiple Resistance at No Cost: Rifampicin and Streptomycin a Dangerous Liaison in the Spread of Antibiotic Resistance
por: Durão, Paulo, et al.
Publicado: (2015)

Genomic Signatures of Sexual Selection on Pollen-Expressed Genes in Arabis alpina
por: Gutiérrez-Valencia, Juanita, et al.
Publicado: (2021)

Antibiotic Cycling Affects Resistance Evolution Independently of Collateral Sensitivity
por: Brepoels, Pauline, et al.
Publicado: (2022)

Natural Selection Canalizes Expression Variation of Environmentally Induced Plasticity-Enabling Genes
por: Shaw, Joseph R., et al.
Publicado: (2014)

Plasticity and Stereotypic Rewiring of the Transcriptome Upon Bacterial Evolution of Antibiotic Resistance
por: Grézal, Gábor, et al.
Publicado: (2023)

Growth-dependent Gene Expression Variation Influences the Strength of Codon Usage Biases
por: Johnson, Mackenzie M, et al.
Publicado: (2023)

Is the Mutation Rate Lower in Genomic Regions of Stronger Selective Constraints?
por: Liu, Haoxuan, et al.
Publicado: (2022)

Alternative Evolutionary Paths to Bacterial Antibiotic Resistance Cause Distinct Collateral Effects
por: Barbosa, Camilo, et al.
Publicado: (2017)

Compatibility of Evolutionary Responses to Constituent Antibiotics Drive Resistance Evolution to Drug Pairs
por: Jahn, Leonie Johanna, et al.
Publicado: (2021)

Balancing Selection for Pathogen Resistance Reveals an Intercontinental Signature of Red Queen Coevolution
por: Bourgeois, Yann, et al.
Publicado: (2021)

Rapid Decline of Ceftazidime Resistance in Antibiotic-Free and Sublethal Environments Is Contingent on Genetic Background
por: Hernando-Amado, Sara, et al.
Publicado: (2022)

Adaptive Mutations in RNA Polymerase and the Transcriptional Terminator Rho Have Similar Effects on Escherichia coli Gene Expression
por: González-González, Andrea, et al.
Publicado: (2017)

Demographic History and Natural Selection Shape Patterns of Deleterious Mutation Load and Barriers to Introgression across Populus Genome
por: Liu, Shuyu, et al.
Publicado: (2022)

Testing the Role of Genetic Background in Parallel Evolution Using the Comparative Experimental Evolution of Antibiotic Resistance
por: Vogwill, Tom, et al.
Publicado: (2014)

Adaptation to Parasites and Costs of Parasite Resistance in Mutator and Nonmutator Bacteria
por: Wielgoss, Sébastien, et al.
Publicado: (2016)

Opsin Gene Duplication in Lepidoptera: Retrotransposition, Sex Linkage, and Gene Expression
por: Mulhair, Peter O, et al.
Publicado: (2023)

Positive Selection during the Evolution of the Blood Coagulation Factors in the Context of Their Disease-Causing Mutations
por: Rallapalli, Pavithra M., et al.
Publicado: (2014)

The Antibiotic Efflux Protein TolC Is a Highly Evolvable Target under Colicin E1 or TLS Phage Selection
por: Tamer, Yusuf Talha, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_60kc5230hr358lvt5g4uabnm0i