Cargando…
The PARK10 gene USP24 is a negative regulator of autophagy and ULK1 protein stability
Recent studies indicate a causative relationship between defects in autophagy and dopaminergic neuron degeneration in Parkinson disease (PD). However, it is not fully understood how autophagy is regulated in the context of PD. Here we identify USP24 (ubiquitin specific peptidase 24), a gene located...
Autores principales: | Thayer, Julia A., Awad, Ola, Hegdekar, Nivedita, Sarkar, Chinmoy, Tesfay, Henok, Burt, Cameran, Zeng, Xianmin, Feldman, Ricardo A., Lipinski, Marta M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984603/ https://www.ncbi.nlm.nih.gov/pubmed/30957634 http://dx.doi.org/10.1080/15548627.2019.1598754 |
Ejemplares similares
-
N-Acetyl-l-leucine improves functional recovery and attenuates cortical cell death and neuroinflammation after traumatic brain injury in mice
por: Hegdekar, Nivedita, et al.
Publicado: (2021) -
PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma
por: Sarkar, Chinmoy, et al.
Publicado: (2019) -
Autophagy protein ULK1 interacts with and regulates SARM1 during axonal injury
por: Choi, Harry M. C., et al.
Publicado: (2022) -
Inhibition of autophagy in microglia and macrophages exacerbates innate immune responses and worsens brain injury outcomes
por: Hegdekar, Nivedita, et al.
Publicado: (2023) -
The deubiquitinase Leon/USP5 interacts with Atg1/ULK1 and antagonizes autophagy
por: Pai, Yueh-Ling, et al.
Publicado: (2023)