Thymidine phosphorylase and prostrate cancer cell proliferation inhibitory activities of synthetic 4-hydroxybenzohydrazides: In vitro, kinetic, and in silico studies

Over-expression of thymidine phosphorylase (TP) plays a key role in many pathological complications, including angiogenesis which leads to cancer cells proliferation. Thus in search of new anticancer agents, a series of 4-hydroxybenzohydrazides (1–29) was synthesized, and evaluated for in vitro thym...

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Detalles Bibliográficos
Autores principales: Javaid, Sumaira, Saad, Syed Muhammad, Zafar, Humaira, Malik, Rizwana, Khan, Khalid Mohammed, Choudhary, M. Iqbal, Rahman, Atta-ur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984732/
https://www.ncbi.nlm.nih.gov/pubmed/31986186
http://dx.doi.org/10.1371/journal.pone.0227549

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984732/
https://www.ncbi.nlm.nih.gov/pubmed/31986186
http://dx.doi.org/10.1371/journal.pone.0227549

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