Biorelevant In Vitro Release Testing and In Vivo Study of Extended-Release Niacin Hydrophilic Matrix Tablets

Niacin (nicotinic acid, NA) is administered orally as an antihyperlipidemic agent in extended-release (ER) tablets in high doses. Due to rapid absorption and extensive metabolism (non-linear pharmacokinetics), the drug plasma levels are highly variable, which may correlate with side effects. Interes...

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Detalles Bibliográficos
Autores principales: Milanowski, Bartłomiej, Hejduk, Arkadiusz, Bawiec, Marek A., Jakubowska, Emilia, Urbańska, Agnieszka, Wiśniewska, Anna, Garbacz, Grzegorz, Lulek, Janina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985042/
https://www.ncbi.nlm.nih.gov/pubmed/31989330
http://dx.doi.org/10.1208/s12249-019-1600-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985042/
https://www.ncbi.nlm.nih.gov/pubmed/31989330
http://dx.doi.org/10.1208/s12249-019-1600-z

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