Cancer Cells Expressing Oncogenic Rat Sarcoma Show Drug-Addiction Toward Epidermal Growth Factor Receptor Antibodies Mediated by Sustained MAPK Signaling

Epidermal growth factor receptor (EGFR) antibodies may have detrimental effects in patients with metastatic colorectal cancer expressing oncogenic Rat sarcoma (RAS). Since a significant number of patients acquire RAS-mediated resistance during EGFR-directed treatment, understanding the molecular mec...

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Detalles Bibliográficos
Autores principales: Tintelnot, Joseph, Metz, Sina, Trentmann, Marie, Oberle, Anna, von Wenserski, Lisa, Schultheiß, Christoph, Braig, Friederike, Kriegs, Malte, Fehse, Boris, Riecken, Kristoffer, Bokemeyer, Carsten, Stein, Alexander, Binder, Mascha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985072/
https://www.ncbi.nlm.nih.gov/pubmed/32039027
http://dx.doi.org/10.3389/fonc.2019.01559

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985072/
https://www.ncbi.nlm.nih.gov/pubmed/32039027
http://dx.doi.org/10.3389/fonc.2019.01559

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