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A general covalent binding model between cytotoxic selenocompounds and albumin revealed by mass spectrometry and X-ray absorption spectroscopy
Selenocompounds (SeCs) are promising therapeutic agents for a wide range of diseases including cancer. The treatment results are heterogeneous and dependent on both the chemical species and the concentration of SeCs. Moreover, the mechanisms of action are poorly revealed, which most probably is due...
Autores principales: | Zheng, Wenyi, He, Rui, Boada, Roberto, Subirana, Maria Angels, Ginman, Tobias, Ottosson, Håkan, Valiente, Manuel, Zhao, Ying, Hassan, Moustapha |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985102/ https://www.ncbi.nlm.nih.gov/pubmed/31988319 http://dx.doi.org/10.1038/s41598-020-57983-y |
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