Cargando…

Primary cilia control cell alignment and patterning in bone development via ceramide-PKCζ-β-catenin signaling

Intraflagellar transport (IFT) proteins are essential for cilia assembly and function. IFT protein mutations lead to ciliopathies, which manifest as variable skeletal abnormalities. However, how IFT proteins regulate cell alignment during bone development is unknown. Here, we show that the deletion...

Descripción completa

Detalles Bibliográficos
Autores principales: Lim, Jormay, Li, Xinhua, Yuan, Xue, Yang, Shuting, Han, Lin, Yang, Shuying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985158/
https://www.ncbi.nlm.nih.gov/pubmed/31988398
http://dx.doi.org/10.1038/s42003-020-0767-x