Affinity-matured variants derived from nimotuzumab keep the original fine specificity and exhibit superior biological activity

Nimotuzumab is a humanized monoclonal antibody against the Epidermal Growth Factor Receptor with a long history of therapeutic use, recognizing an epitope different from the ones targeted by other antibodies against the same antigen. It is also distinguished by much less toxicity resulting in a bett...

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Detalles Bibliográficos
Autores principales: Tundidor, Yaima, Ponce, Luis F., Chao, Lisset, Solozábal, Joaquín, Hust, Michael, Dübel, Stefan, Rojas, Gertrudis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985160/
https://www.ncbi.nlm.nih.gov/pubmed/31988343
http://dx.doi.org/10.1038/s41598-019-57279-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985160/
https://www.ncbi.nlm.nih.gov/pubmed/31988343
http://dx.doi.org/10.1038/s41598-019-57279-w

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