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Affinity-matured variants derived from nimotuzumab keep the original fine specificity and exhibit superior biological activity
Nimotuzumab is a humanized monoclonal antibody against the Epidermal Growth Factor Receptor with a long history of therapeutic use, recognizing an epitope different from the ones targeted by other antibodies against the same antigen. It is also distinguished by much less toxicity resulting in a bett...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985160/ https://www.ncbi.nlm.nih.gov/pubmed/31988343 http://dx.doi.org/10.1038/s41598-019-57279-w |