SETD2 mutation in renal clear cell carcinoma suppress autophagy via regulation of ATG12

Inactivating mutations in the SETD2 gene, encoding for a nonredundant histone H3 methyltransferase and regulator of transcription, is a frequent molecular feature in clear cell renal cell carcinomas (ccRCC). SETD2 deficiency is associated with recurrence of ccRCC and bears low prognostic values. Tar...

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Detalles Bibliográficos
Autores principales: González-Rodríguez, Patricia, Engskog-Vlachos, Pinelopi, Zhang, Hanzhao, Murgoci, Adriana-Natalia, Zerdes, Ioannis, Joseph, Bertrand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985262/
https://www.ncbi.nlm.nih.gov/pubmed/31988284
http://dx.doi.org/10.1038/s41419-020-2266-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985262/
https://www.ncbi.nlm.nih.gov/pubmed/31988284
http://dx.doi.org/10.1038/s41419-020-2266-x

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