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Alternative Lengthening of Telomeres in Pediatric Cancer: Mechanisms to Therapies
Achieving replicative immortality is a crucial step in tumorigenesis and requires both bypassing cell cycle checkpoints and the extension of telomeres, sequences that protect the distal ends of chromosomes during replication. In the majority of cancers this is achieved through the enzyme telomerase,...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985284/ https://www.ncbi.nlm.nih.gov/pubmed/32039009 http://dx.doi.org/10.3389/fonc.2019.01518 |