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Constitutive CD8 expression drives innate CD8(+) T-cell differentiation via induction of iNKT2 cells
Temporal down-regulation of the CD8 co-receptor after receiving positive-selection signals has been proposed to serve as an important determinant to segregate helper versus cytotoxic lineages by generating differences in the duration of TCR signaling between MHC-I and MHC-II selected thymocytes. By...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Life Science Alliance LLC
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985454/ https://www.ncbi.nlm.nih.gov/pubmed/31980555 http://dx.doi.org/10.26508/lsa.202000642 |