Targeted activation of Stat3 in combination with paclitaxel results in increased apoptosis in epithelial ovarian cancer cells and a reduced tumour burden

OBJECTIVES: Stat3 is persistently activated in ovarian cancer cells, with a crucial role in tumour onset and progression. In this study, we examined the anti‐tumour effect of a small‐molecule inhibitor napabucasin (BBI608) on epithelial ovarian cancer (EOC) in vitro and in vivo, and investigated the...

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Detalles Bibliográficos
Autores principales: Li, Hongyi, Qian, Yanping, Wang, Xi, Pi, Ruyu, Zhao, Xia, Wei, Xiawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985655/
https://www.ncbi.nlm.nih.gov/pubmed/31778258
http://dx.doi.org/10.1111/cpr.12719

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985655/
https://www.ncbi.nlm.nih.gov/pubmed/31778258
http://dx.doi.org/10.1111/cpr.12719

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