Gamabufotalin induces a negative feedback loop connecting ATP1A3 expression and the AQP4 pathway to promote temozolomide sensitivity in glioblastoma cells by targeting the amino acid Thr794

OBJECTIVES: Temozolomide (TMZ) is one of the most commonly used clinical drugs for glioblastoma (GBM) treatment, but its drug sensitivity needs to be improved. Gamabufotalin (CS‐6), the primary component of the traditional Chinese medicine “ChanSu,” was shown to have strong anti‐cancer activity. How...

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Detalles Bibliográficos
Autores principales: Lan, Yu‐Long, Chen, Cheng, Wang, Xun, Lou, Jia‐Cheng, Xing, Jin‐Shan, Zou, Shuang, Hu, Ji‐Liang, Lyu, Wen, Zhang, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985666/
https://www.ncbi.nlm.nih.gov/pubmed/31746080
http://dx.doi.org/10.1111/cpr.12732

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985666/
https://www.ncbi.nlm.nih.gov/pubmed/31746080
http://dx.doi.org/10.1111/cpr.12732

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