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Bifidobacterium Supplementation of Colostrum and Breast Milk Enhances Weight Gain and Metabolic Responses Associated with Microbiota Establishment in Very-Preterm Infants

BACKGROUND: Postnatal growth restriction in very-preterm infants (VPIs) may have long-lasting effects. Recent evidence suggests that developmental problems in VPIs are related to abnormalities in intestinal microbial communities. OBJECTIVE: To investigate the effect on growth outcomes in VPIs of sup...

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Autores principales: Oshiro, Tatsuo, Nagata, Satoru, Wang, Chongxin, Takahashi, Takuya, Tsuji, Hirokazu, Asahara, Takashi, Nomoto, Koji, Takei, Hajime, Nittono, Hiroshi, Yamashiro, Yuichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985890/
https://www.ncbi.nlm.nih.gov/pubmed/31993433
http://dx.doi.org/10.1159/000502935
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author Oshiro, Tatsuo
Nagata, Satoru
Wang, Chongxin
Takahashi, Takuya
Tsuji, Hirokazu
Asahara, Takashi
Nomoto, Koji
Takei, Hajime
Nittono, Hiroshi
Yamashiro, Yuichiro
author_facet Oshiro, Tatsuo
Nagata, Satoru
Wang, Chongxin
Takahashi, Takuya
Tsuji, Hirokazu
Asahara, Takashi
Nomoto, Koji
Takei, Hajime
Nittono, Hiroshi
Yamashiro, Yuichiro
author_sort Oshiro, Tatsuo
collection PubMed
description BACKGROUND: Postnatal growth restriction in very-preterm infants (VPIs) may have long-lasting effects. Recent evidence suggests that developmental problems in VPIs are related to abnormalities in intestinal microbial communities. OBJECTIVE: To investigate the effect on growth outcomes in VPIs of supplementation with Bifidobacterium along with mother's colostrum and breast milk. METHODS: A randomized controlled study was performed on 35 VPIs, born between 24 and 31 weeks of gestation with birth weights <1,500 g. The patients received either daily Bifidobacterium breve supplementation (Bifid group) or vehicle supplement only (placebo group). Parenteral nutrition was initiated with glucose, amino acids, and fatty acids for all of the infants soon after birth. Each infant received their own mother's colostrum within 24 h of birth, and breast milk on subsequent days. Fecal bacteria, organic acids, pH, bile acids, and plasma fatty acids were analyzed. RESULTS: Seventeen infants were allocated to the Bifid group and 18 to the placebo group; the birth weights and gestational ages did not differ significantly between the two groups. Compared to the placebo group, the Bifid group showed significantly greater and earlier weight gain by 8 weeks; significantly higher total fecal bacterial counts, including bifidobacteria; higher levels of total fecal short-chain fatty acids and nominally (but not significantly) higher concentrations of plasma n−3 fatty acids; and lower levels of total fecal bile acid. CONCLUSIONS: Bifidobacterial supplementation of maternal colostrum and breast milk yielded the establishment of a beneficial microbiota profile, leading to favorable metabolic responses that appeared to provide improved growth in VPIs.
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spelling pubmed-69858902020-01-28 Bifidobacterium Supplementation of Colostrum and Breast Milk Enhances Weight Gain and Metabolic Responses Associated with Microbiota Establishment in Very-Preterm Infants Oshiro, Tatsuo Nagata, Satoru Wang, Chongxin Takahashi, Takuya Tsuji, Hirokazu Asahara, Takashi Nomoto, Koji Takei, Hajime Nittono, Hiroshi Yamashiro, Yuichiro Biomed Hub Research Article BACKGROUND: Postnatal growth restriction in very-preterm infants (VPIs) may have long-lasting effects. Recent evidence suggests that developmental problems in VPIs are related to abnormalities in intestinal microbial communities. OBJECTIVE: To investigate the effect on growth outcomes in VPIs of supplementation with Bifidobacterium along with mother's colostrum and breast milk. METHODS: A randomized controlled study was performed on 35 VPIs, born between 24 and 31 weeks of gestation with birth weights <1,500 g. The patients received either daily Bifidobacterium breve supplementation (Bifid group) or vehicle supplement only (placebo group). Parenteral nutrition was initiated with glucose, amino acids, and fatty acids for all of the infants soon after birth. Each infant received their own mother's colostrum within 24 h of birth, and breast milk on subsequent days. Fecal bacteria, organic acids, pH, bile acids, and plasma fatty acids were analyzed. RESULTS: Seventeen infants were allocated to the Bifid group and 18 to the placebo group; the birth weights and gestational ages did not differ significantly between the two groups. Compared to the placebo group, the Bifid group showed significantly greater and earlier weight gain by 8 weeks; significantly higher total fecal bacterial counts, including bifidobacteria; higher levels of total fecal short-chain fatty acids and nominally (but not significantly) higher concentrations of plasma n−3 fatty acids; and lower levels of total fecal bile acid. CONCLUSIONS: Bifidobacterial supplementation of maternal colostrum and breast milk yielded the establishment of a beneficial microbiota profile, leading to favorable metabolic responses that appeared to provide improved growth in VPIs. S. Karger AG 2019-09-24 /pmc/articles/PMC6985890/ /pubmed/31993433 http://dx.doi.org/10.1159/000502935 Text en Copyright © 2019 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Research Article
Oshiro, Tatsuo
Nagata, Satoru
Wang, Chongxin
Takahashi, Takuya
Tsuji, Hirokazu
Asahara, Takashi
Nomoto, Koji
Takei, Hajime
Nittono, Hiroshi
Yamashiro, Yuichiro
Bifidobacterium Supplementation of Colostrum and Breast Milk Enhances Weight Gain and Metabolic Responses Associated with Microbiota Establishment in Very-Preterm Infants
title Bifidobacterium Supplementation of Colostrum and Breast Milk Enhances Weight Gain and Metabolic Responses Associated with Microbiota Establishment in Very-Preterm Infants
title_full Bifidobacterium Supplementation of Colostrum and Breast Milk Enhances Weight Gain and Metabolic Responses Associated with Microbiota Establishment in Very-Preterm Infants
title_fullStr Bifidobacterium Supplementation of Colostrum and Breast Milk Enhances Weight Gain and Metabolic Responses Associated with Microbiota Establishment in Very-Preterm Infants
title_full_unstemmed Bifidobacterium Supplementation of Colostrum and Breast Milk Enhances Weight Gain and Metabolic Responses Associated with Microbiota Establishment in Very-Preterm Infants
title_short Bifidobacterium Supplementation of Colostrum and Breast Milk Enhances Weight Gain and Metabolic Responses Associated with Microbiota Establishment in Very-Preterm Infants
title_sort bifidobacterium supplementation of colostrum and breast milk enhances weight gain and metabolic responses associated with microbiota establishment in very-preterm infants
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985890/
https://www.ncbi.nlm.nih.gov/pubmed/31993433
http://dx.doi.org/10.1159/000502935
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