Neurodegenerative Disease–Associated Variants in TREM2 Destabilize the Apical Ligand-Binding Region of the Immunoglobulin Domain

Single nucleotide variations in Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) have been linked to both late-onset Alzheimer's disease and behavioral variant frontotemporal dementia (FTD), the latter presenting either in isolation or with cystic bone lesions in a condition called Nasu...

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Detalles Bibliográficos
Autores principales: Dean, Hunter B., Roberson, Erik D., Song, Yuhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985895/
https://www.ncbi.nlm.nih.gov/pubmed/32021611
http://dx.doi.org/10.3389/fneur.2019.01252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985895/
https://www.ncbi.nlm.nih.gov/pubmed/32021611
http://dx.doi.org/10.3389/fneur.2019.01252

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