T‐495, a novel low cooperative M(1) receptor positive allosteric modulator, improves memory deficits associated with cholinergic dysfunction and is characterized by low gastrointestinal side effect risk

M(1) muscarinic acetylcholine receptor (M(1)R) activation can be a new therapeutic approach for the treatment of cognitive deficits associated with cholinergic hypofunction. However, M(1)R activation causes gastrointestinal (GI) side effects in animals. We previously found that an M(1)R positive all...

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Detalles Bibliográficos
Autores principales: Mandai, Takao, Sako, Yuu, Kurimoto, Emi, Shimizu, Yuji, Nakamura, Minoru, Fushimi, Makoto, Maeda, Ryouta, Miyamoto, Maki, Kimura, Haruhide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986443/
https://www.ncbi.nlm.nih.gov/pubmed/31990455
http://dx.doi.org/10.1002/prp2.560

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986443/
https://www.ncbi.nlm.nih.gov/pubmed/31990455
http://dx.doi.org/10.1002/prp2.560

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