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T‐495, a novel low cooperative M(1) receptor positive allosteric modulator, improves memory deficits associated with cholinergic dysfunction and is characterized by low gastrointestinal side effect risk
M(1) muscarinic acetylcholine receptor (M(1)R) activation can be a new therapeutic approach for the treatment of cognitive deficits associated with cholinergic hypofunction. However, M(1)R activation causes gastrointestinal (GI) side effects in animals. We previously found that an M(1)R positive all...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986443/ https://www.ncbi.nlm.nih.gov/pubmed/31990455 http://dx.doi.org/10.1002/prp2.560 |