Cargando…

Interactions between TGF-β type I receptor and hypoxia-inducible factor-α mediates a synergistic crosstalk leading to poor prognosis for patients with clear cell renal cell carcinoma

To investigate the significance of expression of HIF-1α, HIF-2α, and SNAIL1 proteins; and TGF-β signaling pathway proteins in ccRCC, their relation with clinicopathological parameters and patient’s survival were examined. We also investigated potential crosstalk between HIF-α and TGF-β signaling pat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mallikarjuna, Pramod, Raviprakash, Tumkur Sitaram, Aripaka, Karthik, Ljungberg, Börje, Landström, Marene
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986558/ https://www.ncbi.nlm.nih.gov/pubmed/31339433 http://dx.doi.org/10.1080/15384101.2019.1642069

Ejemplares similares

Transforming growth factor-β promotes aggressiveness and invasion of clear cell renal cell carcinoma
por: Sitaram, Raviprakash T., et al.
Publicado: (2016)

VHL status regulates transforming growth factor-β signaling pathways in renal cell carcinoma
por: Mallikarjuna, Pramod, et al.
Publicado: (2018)

The Synergistic Cooperation between TGF-β and Hypoxia in Cancer and Fibrosis
por: Mallikarjuna, Pramod, et al.
Publicado: (2022)

Single Nucleotide Polymorphisms in the Wilms’ Tumour Gene 1 in Clear Cell Renal Cell Carcinoma
por: Li, Xingru, et al.
Publicado: (2013)

Telomere Length in Relation to Immunological Parameters in Patients with Renal Cell Carcinoma
por: Svenson, Ulrika, et al.
Publicado: (2013)

Combined Transcriptomic and Protein Array Cytokine Profiling of Human Stem Cells from Dental Apical Papilla Modulated by Oral Bacteria
por: Zymovets, Valeriia, et al.
Publicado: (2022)

TGFβ activates PI3K-AKT signaling via TRAF6
por: Song, Jie, et al.
Publicado: (2017)

The Notch and TGF-β Signaling Pathways Contribute to the Aggressiveness of Clear Cell Renal Cell Carcinoma
por: Sjölund, Jonas, et al.
Publicado: (2011)

TRAF6 promotes TGFβ-induced invasion and cell-cycle regulation via Lys63-linked polyubiquitination of Lys178 in TGFβ type I receptor
por: Sundar, Reshma, et al.
Publicado: (2015)

The 2019 FASEB Science Research Conference on the TGF-β Superfamily: Signaling in Development and Disease, July 28 to August 2, 2019, West Palm Beach, Florida, USA
por: Landström, Marene, et al.
Publicado: (2019)

CIN85 modulates TGFβ signaling by promoting the presentation of TGFβ receptors on the cell surface
por: Yakymovych, Ihor, et al.
Publicado: (2015)

TRAF6 function as a novel co-regulator of Wnt3a target genes in prostate cancer
por: Aripaka, Karthik, et al.
Publicado: (2019)

Gas6 and the Receptor Tyrosine Kinase Axl in Clear Cell Renal Cell Carcinoma
por: Gustafsson, Anna, et al.
Publicado: (2009)

APPL proteins promote TGFβ-induced nuclear transport of the TGFβ type I receptor intracellular domain
por: Song, Jie, et al.
Publicado: (2015)

Specific Genomic Aberrations Predict Survival, But Low Mutation Rate in Cancer Hot Spots, in Clear Cell Renal Cell Carcinoma
por: Köhn, Linda, et al.
Publicado: (2015)

Smad7 Enhances TGF-β-Induced Transcription of c-Jun and HDAC6 Promoting Invasion of Prostate Cancer Cells
por: Thakur, Noopur, et al.
Publicado: (2020)

Pro-invasive properties of Snail1 are regulated by sumoylation in response to TGFβ stimulation in cancer
por: Gudey, Shyam Kumar, et al.
Publicado: (2017)

TGFβ-induced invasion of prostate cancer cells is promoted by c-Jun-dependent transcriptional activation of Snail1
por: Thakur, Noopur, et al.
Publicado: (2014)

DNA methylation associates with survival in non-metastatic clear cell renal cell carcinoma
por: Evelönn, Emma Andersson, et al.
Publicado: (2019)

Reduced tumor growth in vivo and increased c-Abl activity in PC3 prostate cancer cells overexpressing the Shb adapter protein
por: Davoodpour, Padideh, et al.
Publicado: (2007)

The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells
por: Song, Jie, et al.
Publicado: (2022)

Alteration of Gene Expression Signatures of Cortical Differentiation and Wound Response in Lethal Clear Cell Renal Cell Carcinomas
por: Zhao, Hongjuan, et al.
Publicado: (2009)

APC and Smad7 link TGFβ type I receptors to the microtubule system to promote cell migration
por: Ekman, Maria, et al.
Publicado: (2012)

Combining epigenetic and clinicopathological variables improves specificity in prognostic prediction in clear cell renal cell carcinoma
por: Andersson-Evelönn, Emma, et al.
Publicado: (2020)

PKCζ facilitates lymphatic metastatic spread of prostate cancer cells in a mice xenograft model
por: Zang, Guangxiang, et al.
Publicado: (2019)

Wilms' tumour 1 can suppress hTERT gene expression and telomerase activity in clear cell renal cell carcinoma via multiple pathways
por: Sitaram, R T, et al.
Publicado: (2010)

Cytokine Secretion, Viability, and Real-Time Proliferation of Apical-Papilla Stem Cells Upon Exposure to Oral Bacteria
por: Rakhimova, Olena, et al.
Publicado: (2021)

Pathway crosstalk enables cells to interpret TGF-β duration
por: Zhang, Jingyu, et al.
Publicado: (2018)

TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer
por: Mu, Yabing, et al.
Publicado: (2011)

Reduced number of CD169(+) macrophages in pre‐metastatic regional lymph nodes is associated with subsequent metastatic disease in an animal model and with poor outcome in prostate cancer patients
por: Strömvall, Kerstin, et al.
Publicado: (2017)

Gene expression pattern of the epidermal growth factor receptor family and LRIG1 in renal cell carcinoma
por: Thomasson, Marcus, et al.
Publicado: (2012)

PAQR5 Expression Is Suppressed by TGFβ1 and Associated With a Poor Survival Outcome in Renal Clear Cell Carcinoma
por: Tao, Chang, et al.
Publicado: (2022)

Progress in survival in renal cell carcinoma through 50 years evaluated in Finland and Sweden
por: Hemminki, Kari, et al.
Publicado: (2021)

CD 9 and vimentin distinguish clear cell from chromophobe renal cell carcinoma
por: Williams, Ariel A, et al.
Publicado: (2009)

TGFβ-induced phosphorylation of Par6 promotes migration and invasion in prostate cancer cells
por: Mu, Y, et al.
Publicado: (2015)

A psychometric evaluation of the Functional assessment of cancer therapy—kidney symptom index (FKSI-19) among renal cell carcinoma patients suggesting an alternative two-factor structure
por: Rosenblad, Andreas Karlsson, et al.
Publicado: (2021)

Crosstalk between p53 and TGF-β Signalling
por: Elston, Rebecca, et al.
Publicado: (2012)

Cancer Characteristics and Current Treatments of Patients with Renal Cell Carcinoma in Sweden
por: Thorstenson, Andreas, et al.
Publicado: (2015)

Tumor Cells and Cancer-Associated Fibroblasts: A Synergistic Crosstalk to Promote Thyroid Cancer
por: Fozzatti, Laura, et al.
Publicado: (2020)

Gene Expression Profiling Predicts Survival in Conventional Renal Cell Carcinoma
por: Zhao, Hongjuan, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_l9tcfdetk4hh6th0an6qeikpbc