Biased modulators of NMDA receptors control channel opening and ion selectivity

Allosteric modulators of ion channels typically alter the transitions rates between conformational states without changing the properties of the open pore. We describe here a novel class of positive allosteric modulators of N-methyl D-aspartate receptors (NMDARs) that mediate a calcium-permeable com...

Descripción completa

Detalles Bibliográficos
Autores principales: Perszyk, Riley E., Swanger, Sharon A., Shelley, Chris, Khatri, Alpa, Fernandez-Cuervo, Gabriela, Epplin, Matthew P., Zhang, Jing, Le, Phuong, Bülow, Pernille, Garnier-Amblard, Ethel, Gangireddy, Pavan Kumar Reddy, Bassell, Gary J., Yuan, Hongjie, Menaldino, David S., Liotta, Dennis C., Liebeskind, Lanny S., Traynelis, Stephen F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986806/
https://www.ncbi.nlm.nih.gov/pubmed/31959964
http://dx.doi.org/10.1038/s41589-019-0449-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986806/
https://www.ncbi.nlm.nih.gov/pubmed/31959964
http://dx.doi.org/10.1038/s41589-019-0449-5

Ejemplares similares