High Canonical Wnt/β-Catenin Activity Sensitizes Murine Hematopoietic Stem and Progenitor Cells to DNA Damage

Aging is characterized by the accumulation of DNA damage and a decrease in stem cell functionality, yet molecular mechanisms that limit the maintenance of stem cells in response to DNA damage remain to be delineated. Here we show in mouse models that DNA damage leads to a transient over-activation o...

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Detalles Bibliográficos
Autores principales: Wang, Yiting, Cui, Hui, Tao, Si, Zeng, Ting, Wu, Jianying, Tao, Zhendong, Zhang, Liu, Zou, Bing, Chen, Zhiyang, Garside, George B., Tang, Duozhuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987068/
https://www.ncbi.nlm.nih.gov/pubmed/31797147
http://dx.doi.org/10.1007/s12015-019-09930-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987068/
https://www.ncbi.nlm.nih.gov/pubmed/31797147
http://dx.doi.org/10.1007/s12015-019-09930-2

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