TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential

TrkH is a bacterial ion channel implicated in K(+) uptake and pH regulation. TrkH assembles with its regulatory protein, TrkA, which closes the channel when bound to ADP and opens it when bound to ATP. However, it is unknown how nucleotides control the gating of TrkH through TrkA. Here we report the...

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Detalles Bibliográficos
Autores principales: Zhang, Hanzhi, Pan, Yaping, Hu, Liya, Hudson, M. Ashley, Hofstetter, Katrina S., Xu, Zhichun, Rong, Mingqiang, Wang, Zhao, Prasad, B. V. Venkataram, Lockless, Steve W., Chiu, Wah, Zhou, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987127/
https://www.ncbi.nlm.nih.gov/pubmed/31992706
http://dx.doi.org/10.1038/s41467-019-14240-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987127/
https://www.ncbi.nlm.nih.gov/pubmed/31992706
http://dx.doi.org/10.1038/s41467-019-14240-9

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