Large deletions in immunoglobulin genes are associated with a sustained absence of DNA Polymerase η

Somatic hypermutation of immunoglobulin genes is a highly mutagenic process that is B cell-specific and occurs during antigen-driven responses leading to antigen specificity and antibody affinity maturation. Mutations at the Ig locus are initiated by Activation-Induced cytidine Deaminase and are equ...

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Detalles Bibliográficos
Autores principales: Lerner, Leticia K., Nguyen, Thuy V., Castro, Ligia P., Vilar, Juliana B., Munford, Veridiana, Le Guillou, Morwenna, Mohammad, Mahwish Mian, Vergé, Véronique, Rosselli, Filippo, Menck, Carlos F. M., Sarasin, Alain, Aoufouchi, Said
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987143/
https://www.ncbi.nlm.nih.gov/pubmed/31992747
http://dx.doi.org/10.1038/s41598-020-58180-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987143/
https://www.ncbi.nlm.nih.gov/pubmed/31992747
http://dx.doi.org/10.1038/s41598-020-58180-7

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