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Large deletions in immunoglobulin genes are associated with a sustained absence of DNA Polymerase η
Somatic hypermutation of immunoglobulin genes is a highly mutagenic process that is B cell-specific and occurs during antigen-driven responses leading to antigen specificity and antibody affinity maturation. Mutations at the Ig locus are initiated by Activation-Induced cytidine Deaminase and are equ...
Autores principales: | Lerner, Leticia K., Nguyen, Thuy V., Castro, Ligia P., Vilar, Juliana B., Munford, Veridiana, Le Guillou, Morwenna, Mohammad, Mahwish Mian, Vergé, Véronique, Rosselli, Filippo, Menck, Carlos F. M., Sarasin, Alain, Aoufouchi, Said |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987143/ https://www.ncbi.nlm.nih.gov/pubmed/31992747 http://dx.doi.org/10.1038/s41598-020-58180-7 |
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