Potent inhibition of HIV replication in primary human cells by novel synthetic polyketides inspired by Aureothin

Overcoming the global health threat of HIV infection requires continuous pipelines of novel drug candidates. We identified the γ-pyrone polyketides Aureothin/Neoaureothin as potent hits by anti-HIV screening of an extensive natural compound collection. Total synthesis of a structurally diverse group...

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Detalles Bibliográficos
Autores principales: Herrmann, Alexander, Roesner, Manfred, Werner, Thomas, Hauck, Stefanie M., Koch, Alisha, Bauer, Amelie, Schneider, Martha, Brack-Werner, Ruth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987146/
https://www.ncbi.nlm.nih.gov/pubmed/31992748
http://dx.doi.org/10.1038/s41598-020-57843-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987146/
https://www.ncbi.nlm.nih.gov/pubmed/31992748
http://dx.doi.org/10.1038/s41598-020-57843-9

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